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pentobarbital will lower the extent or influence of fentanyl intranasal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Closely. Coadministration of fentanyl with CYP3A4 inducers may lead to some lessen in fentanyl plasma concentrations, not enough efficacy or, quite possibly, progress of a withdrawal syndrom

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